Creatinine more than 1100μmol/L usually indicates a severe decline in renal function, which may be life-threatening. It should be consulted promptly and treated for the cause. If the patient has no history of renal disease, normal creatinine, and now creatinine 1100μmol/L, it is usually considered to be acute renal injury, active causal treatment, correcting reversible factors, and hemodialysis treatment if necessary. If the patient has a history of chronic kidney disease, creatinine 1100 μmol / L more, indicating that it has reached the uremic stage. Patients often have serious clinical symptoms, such as generalized edema, or even pleural fluid and ascites, shortness of breath; gastrointestinal symptoms, such as nausea, vomiting, loss of appetite; the patient’s general state is very poor, with anemic appearance, fatigue, and in severe cases, even complicate uremic encephalopathy. Blood purification or kidney transplantation is needed. If the patient found creatinine 1100μmol / L more, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.