High-grade adenoma of gallbladder is a pathological diagnosis, belonging to adenomatous polypoid lesion of gallbladder, which is a benign tumor of gallbladder, and the main treatments are surgical treatment, regular follow-up treatment and so on. 1. Surgical treatment: gallbladder adenoma is a precancerous lesion, which should be treated by surgery, and can be cured after surgical resection. Laparoscopic cholecystectomy is recommended, and common indications for surgery are: The common indications for surgery are: single lesion with a diameter of >1cm; combined with gallbladder stones and cholecystitis; small lesion located in the neck of the gallbladder, which affects the function of the gallbladder or produces biliary colic; widened and enlarged lesion within a short period of time; combined with biliary cholangitis in multiple lesions; and age of >50 years old. 2. Conservative treatment: For patients who do not need surgical treatment, regular follow-up should be conducted, and it is recommended that a review should be conducted every 3-6 months; for lesions with malignant tendency, surgical resection should be performed. For patients diagnosed with gallbladder adenoma, they should immediately go to the relevant departments of regular hospitals and be treated under the guidance of professional physicians, so as to avoid delaying the condition and leading to deterioration.