The occurrence of gastroesophageal reflux disease is very closely related to emotional changes. With the rapid development of modern medicine, the psychosocial model has gradually attracted attention. Mental stimulation and emotional fluctuations can induce or cause abnormalities in the secretion and movement of the digestive tract in a variety of ways and through a variety of pathways, including neurohumoral. The occurrence and recurrence of gastroesophageal reflux disease also has the participation of factors in this regard. Making good emotional adjustment and building confidence in overcoming the disease are of great significance in relieving symptoms and preventing recurrence. So how to adjust emotions? First of all, to build confidence. Due to the long duration of GERD, recurrence of symptoms, treatment is difficult, patients often from the initial positive treatment to gradually confidence, to the final discouragement, give up treatment. There are also patients who frequently change their primary care physicians due to poor short-term results, leading to irritability and anxiety, which in turn aggravate the disease. The correct approach is to fully understand the disease, especially the severity of their disease, development trends and prognosis to fully understand. On this basis, maintain optimism, establish confidence in overcoming the disease, comply with medical advice, standardize treatment, and take medication according to the course of treatment. Secondly, patients should also maintain a calm state of mind in daily life and try to avoid excessive and undesirable emotional stimulation. The ancient saying: “calm and void, the true energy from it, the spirit within the guard, the disease is safe from is a certain scientific reason. People always have seven feelings and six desires, it is difficult to get rid of the mortal world, the key is to deal with the problem rationally, control the emotions. Or too happy, too sad, or too angry, too afraid, or depressed, thinking about the lack of knots, or sleep and food, just think what is more important than life and health. Of course, everyone has privacy, for the unspeakable pain, difficult to confide in people’s hearts, appropriate change of environment, distraction, release pressure is also very necessary. Finally, emotional communication with friends and family and communication with doctors should be strengthened. Gastroesophageal reflux disease has a long course, during which the disease inevitably recurs, many times there will be anxiety, irritability, lack of confidence, and at this time, the comfort and understanding of relatives, effective communication with doctors, is the patient’s persistent treatment, the spiritual support to overcome the disease.