In the current living conditions, the number of patients with cranial defects is gradually increasing, however, the defects bring serious harm to the body. Scalp and skull defects can be categorized into congenital and traumatic according to their causes. Congenital scalp and skull defects are rare, and clinically, they are mainly acquired scalp and skull defects caused by various kinds of trauma. Traumatic scalp defects are often caused by scalp avulsion, deep burns, electric shock, traffic accidents, etc. They can also be seen in severe infections, osteomyelitis or after tumor resection. According to the depth of their injury, they can be divided into two categories: partial scalp defects (cranial membrane present) and total scalp defects (cranial membrane defects). In the treatment of craniocerebral trauma and some brain diseases, desmoidal decompression is the first choice among the second-line methods for the treatment of malignant high cranial pressure, desmoidal decompression is able to effectively reduce intracranial pressure and reduce the compression of the brainstem vital centers. And this will inevitably lead to more and more cases of cranial defects. Cranial defects cause changes in cerebral pressure, which increases the risk of hydrocephalus and atrophy and affects the recovery of brain function, which can be life-threatening in severe cases. Therefore, timely repair of cranial defects is essential. We have developed a new type of polyether ether ketone peek material as a cranial bone repair, peek material can accurately replicate the defective part of the human skull, based on CT data through the advanced 3D printing technology to reconstruct the design, and the defective area to accurately match, to meet the patient for the wound recovery of the high demand for perfection. peek is the patient’s high quality choice of the good material.