Esophageal cancer T2N0M0 suggests that patients are recommended to treat it by means of esophagectomy. Esophageal cancer T2N0M0 indicates that the tumor invades the intrinsic muscular layer, but there is no regional lymph node metastasis or distant metastasis. According to the tips of Esophageal Cancer Diagnostic and Treatment Guidelines, it is recommended that patients should be treated by esophagectomy, and if the tumor is closely related to the peripheral tissues, it can be treated with adjuvant chemotherapy before evaluating the timing of surgery. The prognosis is generally better, with lower probability of recurrence and metastasis. Radiotherapy is the primary treatment for patients who are inoperable, do not undergo surgery, or for whom surgery is difficult. After the disease has been treated by transesophagectomy, regular follow-ups are necessary to avoid recurrence of the disease. If there is any discomfort, it is recommended to consult a doctor in time to avoid delay.