GBP surgery, or gastric diversion surgery, is a relatively mature surgical procedure for the radical treatment of diabetes. It originated in the 1950s in developed countries in Europe and the United States. At that time, many obese patients who were influenced by fashionable aesthetics demanded surgery to lose weight. The procedure was the most primitive form of gastric diversion. The clinical observation of the University of Iowa in the United States found that the condition of type 2 diabetes was significantly improved and blood glucose stabilized to normal level after surgery in obese patients, but this phenomenon did not attract attention. It was not until 1998 that East Carolina University reported the results of a 30-year follow-up study of gastric diversion bariatric surgery in a world-renowned medical journal, once again proving the fact that diabetes improved in obese patients after gastric diversion bariatric surgery, and only then did it attract great attention from the academic community. The International Diabetes Center, in conjunction with experts from many countries, conducted in-depth research on gastric diversion (GBP) surgery for diabetes, and GBP surgery was therefore rapidly applied in clinical practice and gradually improved, so that the main beneficiaries of GBP surgery also shifted from obese patients to type 2 diabetes patients. After more than 20 years of dedicated research and clinical practice by scholars from many countries around the world, the technique has become fully mature. Due to the proven technology of Gastrointestinal Diversion (GBP) surgery in the treatment of diabetes, it has a 100% efficiency rate and 96.25% cure rate for type 2 diabetes. Mechanism of surgery Under normal circumstances, food passes through the stomach, duodenum, jejunum and ileum and is digested and absorbed. Gastric diversion surgery changes the physiological flow of food through partial gastric block, gastrointestinal anastomosis, and enteroenteric anastomosis without removing any tissue or organ. The postoperative digestive tract is divided into two regions: i. Food diversion zone: This refers to the distal stomach, duodenum and part of the proximal jejunum. Inside this part of the digestive lumen, there are a large number of K cells distributed on the mucosa. As soon as they are stimulated by food, K cells secrete a large number of cytokines, which are collectively called insulin resistance factors, causing the body to develop insulin resistance, which is the most initial reason for the formation of diabetes. This is the initial reason for the formation of diabetes. If you do a diversion, the upper gastrointestinal tract no longer receives food stimulation, the insulin resistance factor secreted by K cells disappears and the body’s insulin resistance phenomenon is weakened, thus removing the initial cause of diabetes. Second, food flow through the area: namely, the proximal stomach, distal jejunum and ileum. This section of the digestive tract accepts undigested or incompletely digested food in advance, leading to an increase in the secretion of some cytokines such as endocrine regulatory peptide (PYY) and GP1. These cytokines have the following common effects: A: directly lowering blood sugar; B: reducing the rate of islet cell apoptosis; C: increasing insulin sensitivity through the “intestine-islet axis”, while promoting insulin secretion, reducing islet apoptosis and proliferation, and stimulating islet cell value-added; D: protecting islet cells from glucose toxicity and other inflammatory diseases. toxicity and other inflammatory hazards. This way the etiology that causes islet apoptosis is also removed. In summary, after the surgery, both causes disappear and diabetes is cured. Indications 1. Type 2 diabetes; 2. Islet function in the compensatory phase (fasting C-peptide value > 2); 3. Age ≤ 65 years (not absolute, but mainly based on the general condition of the body and the residual function of the islets).