Mirtazapine is not effective in the treatment of migraine and is not recommended. Migraine medication includes acute-phase medication (such as nonsteroidal drugs, tretinoin and ergotamine) and prophylactic medication (such as beta-blockers, antiepileptic drugs, etc.). 1. Non-steroidal drugs such as diclofenac sodium are recommended for acute attacks, with adverse effects such as gastric mucosal damage and asthma attacks, and are contraindicated in patients with gastric ulcers and bleeding tendency; and tretinoin drugs such as sumatriptan, with adverse effects such as fatigue, gastrointestinal reactions, and myocardial infarction, are contraindicated in patients with ischemic heart disease and uncontrolled hypertension. 2. Prophylactic use of recommended β-blockers such as propranolol, adverse reactions for heart failure, bradycardia, hypotension, rash, etc., prohibited in patients with cardiogenic shock, asthma, acidosis; antiepileptic drugs such as sodium valproate, adverse reactions for liver function abnormalities, rash, fatigue, etc., prohibited in liver disease, women of childbearing age. Mirtazapine belongs to the anti-psychotics, the treatment of migraine is not effective, it is recommended that patients who are not adapted to timely medical treatment, the use of drugs under the guidance of a physician, do not blindly use their own medication.