A clear hyperechoic border is an ultrasound description of a lesion that suggests that the lesion is relatively loose in texture and well demarcated from the surrounding tissue. Ultrasound describes a lesion in many ways, and the finding of hypoechoicity suggests that the tissue is relatively loose in texture compared with neighboring tissues, which is usually the case with cystic and soft tissue lesions. Clear borders indicate that the lesion is well demarcated from the surrounding tissue, which is a benign sign. The overall judgment of the lesion should be based on the combination of margins and blood flow. When a hypoechoic lesion with clear borders is detected, it should be analyzed in combination with other ultrasound indexes, laboratory tests, and pathological tests to make a clear diagnosis of the nature of the lesion. Abnormalities require timely medical treatment to avoid delaying the condition.