I. Anticoagulation during menstruation 1. Most people do not have a large amount of menstruation, the amount of anticoagulants used remains the same. 2.If bleeding increases, the amount of warfarin can be reduced. 3.If there is a lot of bleeding, vitamin K1 can be injected to stop the bleeding. 4.If the menstrual bleeding is out of balance and the bleeding continues, menstrual regulating drugs should be taken. 5.Very few large bleeding, hysterectomy is needed. Anticoagulation during pregnancy Warfarin can enter the placenta, and there is a risk of fetal malformation in the first trimester of pregnancy. Heparin cannot cross the placenta, so stop warfarin in the first trimester and inject heparin subcutaneously. If the pregnancy is not suitable to continue, abortion is feasible (for abortion, stop taking warfarin 4-5 days before the operation and operate after normal laboratory tests; or stop warfarin 4-5 days before the operation and inject heparin, and stop heparin 4-6 hours before the operation. (Start anticoagulation 24-48 hours after postoperative bleeding stops, start anticoagulation at the original preoperative dose, and adjust warfarin dosage according to the results of the four coagulation items). Anticoagulation in the perinatal period 1.Change warfarin to heparin 1-2 weeks before the expected date of delivery, and counteract with fisetin if there is much bleeding after delivery, and start to reintroduce oral warfarin 24-48 hours after the delivery of the fetus without signs of bleeding. 2.If the delivery is natural, if you do not stop using warfarin, inject vitamin K1 after the contractions start, and start taking warfarin again if there is no bleeding sign 24-48 hours after the delivery of the fetus. 3.If caesarean section is used, elective surgery will be handled; if emergency surgery is needed, blood will be taken immediately to measure prothrombin time and activity, while vitamin K1 10-20mg will be injected intravenously, and surgery can be performed after normal prothrombin time is rechecked after 4 hours; if time is urgent, surgery can be started after vitamin K1 is injected intravenously without waiting for laboratory results, and bleeding will be stopped 24-48 hours after the operation is carefully stopped. Anticoagulation.