Pioneer drugs, i.e. cephalosporins, generally require patients not to drink alcohol for 7 days after stopping the use of cephalosporins because the drugs will have a disulfiram-like reaction with alcohol in the body, and it takes about 1 week for cephalosporins to be completely metabolized and cleared in the body. Drinking alcohol after taking some cephalosporins can cause disulfiram-like reactions, mainly because some cephalosporins contain N-methylthiotetrazolium (MTT), which can block the continued metabolism of acetaldehyde, a metabolite of ethanol in the body, causing the accumulation of acetaldehyde in the body and causing disulfiram-like reactions. The main manifestations are nausea, flushing, headache, tachycardia, hypotension, etc. In serious cases, anaphylactic shock, loss of consciousness, myocardial infarction, and even death can occur. It takes about 1 week for cephalosporins to be completely metabolized in the body, so it is best for patients to consider drinking alcohol 7 days after stopping the drug. Also, since alcohol can remain in the body for about 12 hours, it is best not to drink alcohol 1-2 days before medication. In addition, nitroimidazoles such as metronidazole, furans such as furazolidone, chloramphenicol, and sulfonylureas such as chlorosulfonylurea can cause disulfiram-like reactions, and alcohol should also be avoided during the use of these drugs.