The main manifestations of pulmonary hypertension are: dyspnea, fatigue, weakness, reduced exercise tolerance angina or chest pain, hoarseness, etc.; its onset is related to heart disease, lung and its vascular pathology, hypoxia, etc. Other unknown causes are still under study. 2005, the People’s Health Press Pediatrics reported: 75% of children with persistent pulmonary hypertension are accompanied by meconium aspiration, suggesting that pulmonary aspiration of gastrointestinal substances can cause this disease. Gastroesophageal reflux disease (GERD) causes pulmonary disease mainly through two ways, 1, neurological reflex 2, direct inhalation irritation damage to the lung mucosa; it is now confirmed that it can cause respiratory symptoms such as cough, wheezing, chest tightness, breath-holding, dyspnea, and extra-digestive symptoms such as chest pain and hoarseness. Through the above analysis, GERD may cause pulmonary hypertension, although there is no clinical study to confirm it, but it needs to be paid attention to.