Disability from lumbar disc herniation secondary to low back pain is a major public health problem and is also the most common cause of activity limitation in young and middle-aged adults. Although it is self-limiting, it can also progress to significant disability, years of workforce loss, and chronic pain. Over the past decade, minimally invasive percutaneous interventional techniques have become mainstream in the treatment of lumbar disc herniation. The aim of this study was to apply minimally invasive interventional techniques to compare the efficacy of medical ozone with radiofrequency combined with medical ozone in the treatment of lumbar disc herniation. Ninety-one adult patients with lumbar disc herniation were randomly and double-blindly divided into two groups: the ozone group received 4-7 ml of oxygen-ozone gas mixture at a concentration of 30 g/ml in the intervertebral disc; the ozone radiofrequency group received ozone group treatment in the intervertebral disc in combination with radiofrequency treatment (radiofrequency temperature of 80°C for 360 s), and the patients were followed up at 2 weeks, 1 month, 3 months, 6 months and 1 year after surgery, respectively. The results showed that at all follow-up points, percutaneous intradiscal ozone combined with radiofrequency was more effective than ozone alone in reducing pain scores, analgesic dosage, improving functional regression, and increasing patient satisfaction. The results showed that percutaneous intradiscal ozone combined with radiofrequency was more effective than ozone alone in reducing pain scores, analgesic dosage, improving functional regression, and increasing satisfaction in patients with lumbar disc herniation, with 92.3% pain reduction at 1-year follow-up.