There are many drugs used for the treatment of epilepsy. At one time we observed for the older generation of antiepileptic drugs, there are seven that are more certain in their efficacy, namely phenytoin sodium, carbamazepine, sodium valproate, phenobarbital, paracetamol, ethosuximide, benzodiazepines (such as diazepam, clonidine, clobazam, etc.), which are also used as first-line drugs. Although these drugs can bring seizures under control in about 60-80% of newly diagnosed epileptic patients, another 20% are refractory or cannot tolerate their toxic side effects. Therefore, new antiepileptic drugs have been used in recent years, especially in recent times when a more rational approach has been to develop new antiepileptic drugs in terms of neurotransmission to the central nervous system. The main purpose is to enhance the inhibitory effect of the central nervous system and/or limit the excitatory amino acid transmission to reduce its excitability. The main drugs that enhance central inhibition are: aminoglutethimide, gabapentin, stilbestrol, flutamide, mirtazapine, and tiagabine. 2. Drugs that reduce excitatory transmission: lamotrigine, oxcarbazepine, zonisamide, and naftifloxacin. 3. Other antiepileptic drugs New drugs are emerging, and the number of treatment options available is increasing, so it is especially important to choose and match them rationally.