The main role of diuretics in lowering blood pressure is to improve sodium and water retention through diuresis, thus reducing the lowering of blood pressure. For the application of diuretics requires a certain choice, most of the types of diuretics applied are hydrochlorothiazide and indapamide. However, in the process of diuretic application, attention must be paid to the monitoring of blood potassium, pay attention not to appear the reduction of blood potassium, and people with increased uric acid should not apply diuretics to lower blood pressure, diuretic antihypertensive drugs can affect the excretion of uric acid, resulting in the elevation of uric acid in humans. The diuretic application is recommended in combination with ARB or ACEI class of drugs, in most cases not applied alone to lower blood pressure, because the side effects of antihypertensive applied alone are more, the general compound like valsartan hydrochlorothiazide tablets, cloxacin potassium hydrochlorothiazide tablets, are applied more.