Fatigue after hyperthyroidism surgery may be related to hypothyroidism, and some levothyroxine can be applied under doctor’s supervision to alleviate the adverse symptoms if necessary. Hyperthyroidism will lead to excessive secretion of thyroid hormone, and if medication is ineffective, surgical treatment may be needed. Most of the thyroid gland will be removed during hyperthyroidism surgery, which will lead to decreased secretion of the thyroid gland, thus leading to hypothyroidism and manifesting some clinical symptoms, such as fatigue and tiredness. Fatigue after hyperthyroidism surgery can be applied with some levothyroxine sodium tablets under doctor’s guidance to balance the level of thyroid hormones in the body and improve the adverse symptoms caused by hypothyroidism. It is recommended to carry out thyroid function tests and targeted treatment under the guidance of the doctor to avoid private abuse of drugs, so as not to delay the condition.