Non-Hodgkin’s lymphoma should be fully assessed for staging, general physical condition, and selection of treatments such as chemotherapy, radiotherapy and targeting. After non-Hodgkin’s lymphoma is clearly diagnosed, systemic examination such as superficial lymph node ultrasound, abdominal ultrasound, chest CT, abdominal CT, and PET-CT examination is feasible when necessary to assess the general tumor condition, perform clinical staging, and choose the best treatment plan according to the staging. For localized lesions that can be treated with radiotherapy, radiotherapy combined with chemotherapy and targeted therapy should be actively selected, which can greatly increase the probability of cure. If the tumor load is large and radiotherapy is not possible, chemotherapy combined with targeted therapy can be chosen, and some patients can also achieve better therapeutic effects. In the course of treatment, care must be taken to evaluate the side effects and how effective the treatment is.