Patients taking reserpine to lower their blood pressure should preferably stop taking it for about 1 week before anesthesia so as to ensure stable blood pressure and surgical safety during the anesthesia. Risperdal is no longer the first-line antihypertensive drug of choice, but some patients are still using its drug to lower blood pressure because of its more definite effect and faster onset of action. The hypotensive effect of reserpine is to block the alpha receptor, which exists directly on the blood vessel. After applying reserpine, the function of the alpha receptor disappears, so that the tension of the blood vessel will be significantly reduced, and it is difficult to reverse the tension with other drugs. Because in the state of anesthesia, if the patient previously applied rifampicin to keep the blood vessels in diastolic state for a long time, it will be insensitive to antihypertensive drugs, and the patient’s blood pressure will be further reduced, even affecting the patient’s life safety. The side effects of reserpine are as follows: rebound phenomenon after stopping the drug; reserpine acts on the center and promotes the release of catecholamine for emptying, which can cause sedation and drowsiness; large doses can lead to depression; it can also cause gastric ulcer, and patients should use the drug under the guidance of doctors.