Hyperthyroidism is a chronic metabolic disease with many causes. Graves’ disease is the most common type of hyperthyroidism, and the typical clinical manifestations of Graves’ disease include the following: a. Hypermetabolic syndrome. Patients with Graves’ disease with hyperthyroidism can develop hypermetabolic symptoms such as fear of heat, excessive sweating, lethargy, agitation, panic, hand tremors, and increased stool frequency. Second, patients with Graves’ disease can develop thyroid disease such as muscle weakness, and can also develop hypokalemic paralysis, and can also involve the heart and develop symptoms of hyperthyroid heart disease such as arrhythmia, heart failure, and heart enlargement. Patients with Graves’ disease can develop diffuse goiter, with a soft texture of the enlarged thyroid gland and palpable tremor in the thyroid area. Patients with Graves’ disease may have unilateral or bilateral protrusion of the eye, or in severe cases, infiltrative proptosis, also known as malignant proptosis.