H. pylori infection usually causes gastritis, peptic ulcer, gastric cancer and other digestive diseases, and there is usually no obvious correlation with coronary heart disease. H. pylori can be transmitted through oral-oral or fecal-oral route, and after entering the human body, it can colonize the gastric mucosa for a long period of time and produce pathogenic factors such as urease and protease, which can cause inflammatory damage to the gastric mucosa. Therefore, Helicobacter pylori infection is closely related to a variety of digestive diseases, such as chronic gastritis, peptic ulcer, gastric cancer. The basic cause of coronary heart disease is the accumulation of plaque on the walls of the coronary arteries, resulting in constant narrowing of the arterial lumen. Its risk factors include smoking, high blood pressure, dyslipidemia, etc. It is usually not significantly correlated with H. pylori infection. Prompt medical treatment is recommended in the presence of these diseases.