If the patient is currently taking timosartan, but the blood pressure still can not come down. In this case, because the patient’s blood pressure is relatively high, it is difficult to control blood pressure up to the standard by taking one antihypertensive drug alone, then a combined antihypertensive program can be initiated. However, before initiating a combined antihypertensive program, it is necessary to ask the patient whether he/she has combined the lifestyle interventions with the improvement of blood pressure, such as whether he/she has a low-salt, low-fat diet, quitting smoking, quitting drinking, and exercising to lose weight in addition to oral antihypertensive drugs, because it is very difficult to control blood pressure up to the standard by simply taking antihypertensive drugs without combining lifestyle interventions. It is difficult to control blood pressure to the standard by simply taking antihypertensive drugs without lifestyle intervention. If the patient is currently complying with the lifestyle interventions, but the blood pressure is still not up to standard, it is recommended that the patient can take calcium channel blockers, combined with timosartan. For example, it can be combined with oral amlodipine, or drugs like nifedipine control tablets or felodipine, which can help lower blood pressure better.