Systemic lupus erythematosus (SLE) is an autoimmune disease that cannot be cured, but can only be controlled without flare-ups, and there is no so-called nemesis, a special drug. The treatment of SLE is currently based on the main principles of delaying the progression of the disease, reducing complications and protecting the function of important organs, which mainly includes general treatment, drug treatment and other treatments, among which drug treatment is the main modality. General treatment mainly includes patient education to make patients understand the disease correctly, eliminate fear, instruct patients to follow medical advice, follow up regularly and understand the necessity of long-term follow-up, avoid excessive exposure to ultraviolet light, and remove various factors affecting the prognosis of the disease, such as controlling blood pressure and preventing infection. Drug therapy mainly includes glucocorticoids and immunosuppressive therapy. Glucocorticoids are mainly used to suppress immune damage, and shock therapy can also be used in critical cases. Immunosuppressants are represented by methotrexate, cyclophosphamide and hydroxychloroquine, and also include cyclosporine, azathioprine, leflunomide and tacrolimus, etc. They are mainly used to reduce the damage caused by SLE by suppressing the immune response. They can be used clinically either alone or in combination. Hydroxychloroquine is currently considered as a background treatment for SLE. Other treatments for SLE mainly include massive immunoglobulin injections, plasma replacement, and autologous stem cell transplantation, but they are not routine treatment items. In addition, Chinese medicine has a role in the treatment of SLE, such as delaying the progression of the disease and reducing adverse drug reactions. Since SLE is a highly heterogeneous disease, drug treatment regimens should be individualized. Clinicians need to develop appropriate drug treatment regimens based on proper evaluation of the severity of the patient’s disease and general physical condition. Since SLE can invade multiple systems and organs of the body, which is more harmful and inevitably affects normal work, life and study, coupled with the fact that long-term use of hormones, immunosuppressants and other drugs can lead to adverse reactions such as obesity, edema, rough skin, osteoporosis and premature aging, many patients are accompanied by adverse emotions such as anxiety and depression, reduce, change or stop medication on their own, or look for so-called Many patients are accompanied by anxiety, depression and other negative emotions, reduce, change or stop their own medication, or look around for the so-called prescriptions, recipes; or pessimistic and anorexic, or even refuse or give up treatment. This will only further aggravate the condition of SLE and measure the best treatment period. On the contrary, those patients who have a good attitude, actively cooperate with treatment and have regular follow-up examinations have better control of lupus disease and high life treatment. Therefore, there is no so-called magic pill for the treatment of SLE, but insisting on systematic and standardized treatment and maintaining a good state of mind is the biggest “nemesis” of SLE.