When choosing antihypertensive drugs for Grade I hypertension, the appropriate antihypertensive drug should be chosen according to the comorbidities. First-degree hypertension can be treated without medication if there are no obvious symptoms as well as complications. For those with Grade I hypertension combined with obesity, diuretics such as hydrochlorothiazide can be chosen. For those with angina pectoris and chronic heart failure, beta-blockers such as propranolol and labetalol can be used. Combined with diabetes mellitus, peripheral vascular disease, can choose calcium channel blockers such as nifedipine. For those with proteinuria and impaired glucose tolerance, angiotensin-converting enzyme inhibitors such as captopril can be chosen. If there is any discomfort during the drug treatment, consult a doctor in time and choose the appropriate treatment drugs under the guidance of a professional doctor.