Generally, lymph node metastasis may disappear with chemotherapy, but the sensitivity of different malignant tumors to chemotherapy is different. Chemotherapy is an important tool used to treat malignant tumors, chemotherapy can be used before surgery or as adjuvant therapy after surgery. Lymph nodes are normal immune organs of human body, and lymph node metastasis means that the tumor is already in advanced stage. For this situation, a combination of surgical treatment and chemotherapy is usually used to relieve the symptoms and prolong the patient’s life. Different malignant tumors have different sensitivities to chemotherapy, and the therapeutic effects are also different. For example, choriocarcinoma and testicular cancer are very sensitive to chemotherapy, and lymph node metastasis can usually be disappeared through chemotherapy. In some middle and advanced malignant tumors, there is still a possibility of recurrence after the disappearance of lymph node metastasis by chemotherapy. Therefore, it is suggested that patients should go to the hospital for regular review under the advice of doctors.