Atorvastatin and Rosuvastatin differ in terms of safety, drug interactions, etc. The mechanism of action, treatment of diseases, etc. are essentially the same. Atorvastatin is a lipophilic statin, which is mainly metabolized by the liver, and there is no need to adjust the dosage when renal insufficiency occurs. Rosuvastatin is a hydrophilic statin that may adversely affect renal function. Therefore, the drug should be used with caution in renal insufficiency. Since atorvastatin is metabolized entirely by the hepatic drug enzyme CPY3A4, and many drugs are metabolized by this route. Rosuvastatin, on the other hand, is metabolized through CPY2C9 and CPY2C19. Therefore, more attention needs to be paid to drug interactions while taking atorvastatin. Both belong to the statin class of drugs, which can play a role in stabilizing plaque and regulating blood lipids, and are mainly used in the treatment of hypercholesterolemia, mixed dyslipidemia and other diseases. It is prohibited for those who are allergic to the ingredients of statin drugs, moderate liver and kidney function impairment, myopathy, pregnancy and lactation. Side effects such as myalgia, headache, constipation and nausea may occur during administration, and it is recommended to use the drug under medical supervision.