The pain felt in the lesion during chemotherapy for osteosarcoma is generally due to the adverse reaction of chemotherapy drugs or the pain caused by the progression of osteosarcoma lesions, which can be treated by symptomatic pain relief or switching to other anti-tumor treatment programs, such as the use of targeted drugs, etc. If the pain is caused by the local stimulation of chemotherapy drugs, the pain is generally not severe. If the pain is caused by local stimulation of osteosarcoma lesions by chemotherapeutic drugs, this kind of pain is generally not serious, and patients are advised to drink more water to promote the excretion of drugs, and the pain will be significantly reduced. Some patients with osteosarcoma are resistant to chemotherapeutic drugs, and there will be pain in the lesion area when the disease progresses after chemotherapy. Generally, strong opioids such as morphine and oxycodone delayed-release tablets are often chosen to provide analgesic treatment, and at the same time, the patient can change to other therapeutic programs for the treatment of osteosarcoma, for example, taking targeted drugs such as amilorotinib. It is recommended that patients with any discomfort promptly consult a doctor to clarify the cause and then actively treat the disease to avoid delays.