Caries-induced toothache can be relieved by oral non-steroidal antipyretic and analgesic drugs, such as ibuprofen extended-release capsules, acetaminophen tablets; combined with compound chlorhexidine solution rinsing to inhibit bacterial proliferation. 1. Non-steroidal analgesics: Ibuprofen extended-release capsules are mainly anti-inflammatory, antipyretic and analgesic; acetaminophen is mainly antipyretic and analgesic. Both are to inhibit the synthesis of prostaglandins and thus play a role in relieving the pain caused by dental caries. It should be used with caution in patients with peptic ulcer. 2. Compound chlorhexidine solution: its main ingredient is chlorhexidine gluconate metronidazole solution, chlorhexidine gluconate is a broad-spectrum antibiotic, and metronidazole treats anaerobic bacteria, so it has a certain effect on the inhibition of bacterial reproduction in the oral cavity, relieving toothache. It is necessary to put forward that the drug treatment can only relieve the symptoms, and can not be cured, caries need to remove the decay and then filling treatment, if the wave of the pulp needs root canal treatment; in addition, when using medication, must be careful to comply with the doctor’s instructions to use drugs, do not arbitrarily use drugs.