Total bilirubin is an indicator of liver function and may manifest as yellowing of the skin and sclera if the total bilirubin is increased by more than double the normal value. In hepatobiliary surgery, increased total bilirubin is mainly caused by obstructive factors, such as stones and tumors in the biliary system and tumors in the pancreas, which may lead to an increase in bilirubin. However, non-pathological conditions, such as staying up late, drinking alcohol, and strenuous exercise, may also lead to a mild transient increase in total bilirubin. It is okay to avoid the cause of this condition, and it can basically return to normal. If the increase in total bilirubin is caused by certain diseases, it is necessary to improve the relevant examination to clarify the specific cause and find the cause before the symptomatic treatment. So clinically, if the total bilirubin is high, don’t worry, first rule out the disease.