Acid reflux can be cured by treatment with omeprazole, domperidone, and bismuth-based medications. The appearance of stomach diseases, such as gastritis, gastric ulcer will lead to excessive secretion of gastric acid, duodenal contents reflux into the esophagus, resulting in patients with heartburn, acid reflux and some other manifestations. First of all, omeprazole is an antacid and anti-ulcer drug, which can effectively inhibit the secretion of gastric acid and protease and reduce the symptoms of acid reflux in patients. Secondly, domperidone is a dopamine receptor blocker, which can promote gastrointestinal dynamics and can play a role in gastric emptying, so it can reduce nausea, vomiting and other manifestations. Finally, the treatment should be accompanied by bismuth drugs, such as colloidal bismuth pectin, which belongs to the mucosal protective agent class of drugs, can produce precipitation in the acidic environment of the stomach after taking, so as to act on the surface of the ulcer, which can prevent the further development of the ulcer, and can play a role in helping the healing and promoting the regeneration of the mucosa.