The treatment of hypertensive nephropathy should strictly control high blood pressure, reasonably use antihypertensive drugs, and actively treat its related complications as follows: 1. Strict control of high blood pressure, reasonable choice of antihypertensive drugs, and at the same time improve renal function can effectively prevent the occurrence and development of hypertensive nephrosclerosis. If hypertensive patients are not combined with diabetes mellitus, and there is no heart, brain and kidney complications, the blood pressure should be reduced to at least 140/90mmHg, and those who can tolerate it can be reduced even lower. For patients with diabetes mellitus and no cardiac, cerebral or renal complications, the blood pressure should be lowered to at least 130/80mmHg, and if the amount of urinary protein excretion is more than 1g/d, the blood pressure should be lowered even more. 2. For patients with persistent and long-term uncontrollable hypertension, the blood pressure should be lowered gradually to prevent too rapid and violent lowering of the blood pressure. For patients with recent sudden increase in blood pressure and rapid deterioration of renal function, strong drug therapy should be given to rapidly normalize blood pressure, intravenous antihypertensive drugs can be preferred, and after blood pressure control, oral antihypertensive drugs should be gradually replaced; 3, a variety of antihypertensive drugs should be combined with conventional dose therapy to reduce adverse drug reactions and improve the therapeutic efficacy; 4, as far as possible to choose long-lasting antihypertensive drugs, so that the blood pressure stabilized in 24 hours to reduce the fluctuation of blood pressure in the target range. The target range of blood pressure should be stabilized within 24 hours to reduce the fluctuation of blood pressure. Long-term application of antihypertensive drugs, need to pay attention to the impact of drugs on glucose metabolism, lipid metabolism and purine metabolism.