Strong echogenic roughness of the gallbladder wall suggests cholecystitis with gallbladder stones, and can also be seen in cirrhosis of the liver, which can be manifested as loss of appetite, pain in the right upper abdomen, nausea, vomiting, etc., and should be promptly referred to a doctor. Normal gallbladder ultrasonography is uniform and smooth, if the gallbladder wall strong echogenic roughness, suggests that there is cholecystitis and accompanied by gallbladder stones, the clinical symptoms of varying degrees of right upper abdominal pain, can be radiated to the back, accompanied by nausea, vomiting, fever, etc., and part of the population can be manifested as dyspepsia, abdominal distension, etc.. Cirrhosis can be characterized by malnutrition, emaciation and fatigue, and in the uncompensated stage of cirrhosis, ascites and gastrointestinal bleeding, and in severe cases, hepatic encephalopathy can occur. People with strong echogenic roughness of gallbladder wall should pay attention to rest, low-fat diet, avoid overeating in daily life.