Bitterness in the morning is usually caused by dampness and heat in the spleen and stomach (the spleen and stomach feel dampness and heat) or dampness and heat in the liver and gallbladder (dampness and heat are accumulated in the liver and gallbladder), and fire in the liver and gallbladder, etc. It can be treated with medicines such as Ginseng Ling Baijutsu San, Gentian Diarrhea Liver Pill, Angelica Longhui Pill and so on. Weakness of the spleen and stomach, which generates heat from dampness and fumigates the liver and gallbladder, can be seen as bitter mouth in the morning, accompanied by fatigue and weakness, and loose stools, which can be treated with Ginseng and Atractylodis Macrocephalae Powder; damp-heat of the liver and gallbladder, and overflow of bile can also be seen as bitter mouth accompanied by yellowish coloration of the body and eyes, which can be treated with Longguan Diarrhea Liver Pill. The symptoms such as bitter mouth, dizziness, red eyes and constipation can also be seen when the liver and gallbladder are on fire and the gallbladder qi overflows, and can be treated with Angelica Longhui Pills. Bitter mouth in the morning is mostly responsible for the spleen and stomach, liver and gallbladder dysfunction, treatment should be accurate identification and selection of drugs, drugs should be taken in accordance with the doctor’s instructions, not arbitrarily use drugs to regulate the treatment.