The patient, a 55-year-old female, was diagnosed with “bronchial asthma” 40 years ago when she developed recurrent cough, chest tightness, shortness of breath, wheezing and dyspnea without any obvious cause, which worsened after activity, and was hospitalized several times and took medication for a long time, but the effect was not satisfactory and her symptoms gradually worsened. He was considered to have “bronchiectasis” and given symptomatic treatment, but still had repeated coughing, chest tightness, shortness of breath, wheezing, dyspnea, intermittent hemoptysis and coughing up pus sputum. 10 years ago, he developed early satiety after meals and could only eat a small amount of food at meals, and could only gradually be relieved by early satiety before the next meal, and had “chronic gastritis”. “2 years ago, the patient began to experience acid reflux and heartburn after eating, which lasted for about 2 hours each time, and food reflux when eating too much, and the symptoms of coughing, coughing, chest tightness, shortness of breath, wheezing and dyspnea became worse. The symptoms of cough, coughing, shortness of breath, shortness of breath and dyspnea are worse. Physical examination: slightly enhanced tactile fibrillation in the chest bilaterally, clear sounds on percussion in both upper lungs, solid sounds in part of both lower lungs, and extensive croup on auscultation in both lungs. No significant abnormalities were found in the rest. Laboratory tests: blood gas showed PH 7.395, PCO2 50 mmHg, PO2 50 mmHg, HCO3 30.6 mmol/L, BE 6 mmol/L, SO2 90%. He was in type II respiratory failure. Chest radiograph showed fibrosis of both lungs, chronic bronchitis, emphysema, and bronchial dilatation. (See Figure 1) (Figure 1) Chest CT showed: extensive fibrosis of both lungs, emphysema, and bronchial dilatation. (See Figure 2) Pulmonary function showed: mixed ventilation dysfunction (moderate obstruction, moderate restriction) with severe deficiency in the percentage of ventilation reserve. The respiratory specialist diagnosed: bronchial asthma, bronchiectasis, emphysema, pulmonary fibrosis, and destroyed lung. Lung transplantation was recommended. (Figure 2) The patient had no choice but to try gastroesophageal reflux examination, esophageal PH monitoring: a total of 12h24min was recorded, the results found that the total number of reflux 46 times, the total reflux time 45min, reflux time accounted for 6.1%, there are 2 reflux time more than 5min, the longest reflux time 9.6min, DeMeester score 24.77. Gastroscopy showed: non- erosive gastroesophageal reflux disease. The patient was given omeprazole 20mg1/day and morpholine 10mg3/day due to poor pulmonary function, and did not continue asthma treatment; respiratory and gastrointestinal symptoms improved significantly, and quality of life also improved significantly. Stretta) under deep sedation. Treatment procedure: fentanyl, midazolam, and isoproterenol were used for intravenous deep sedation. The dentate line was 37 cm from the incisor, the esophageal mucosa was smooth, the vascular network was not clear, the dentate line was blurred and irregular, the cardia was slightly loose; the gastric fundus was normal, the mucus pool was clear and the amount was medium; the mucosa of the gastric body, gastric horn and sinus was still smooth. The guidewire was left in the duodenum through the gastroscope, the endoscope was withdrawn, the radiofrequency treatment catheter was placed into the esophagus along the guidewire, the guidewire was withdrawn, the probe radiofrequency treatment was introduced at 1 cm, 0.5 cm, dentate line, 0.5 cm below the dentate line at 0° and 45° right rotation, respectively, the catheter position was adjusted, the catheter was injected with 25 ml and 22 ml of gas in the balloon, and then the catheter was pulled outward to the appropriate resistance, and the catheter was rotated at 0°, 30° right rotation and 30° left rotation, respectively. 30°, left rotation 30° direction to launch the probe radiofrequency treatment, intramuscular tissue temperature 80-90 ℃, mucosal surface temperature 40-50 ℃, impedance 100-300 ohm. After treatment, review of the gastroscopy saw the lower end of the esophagus and the cardia white dotted cauterized surface, cardia wrapped around the endoscope closely; a small amount of bleeding from the esophagus and cardia mucosa, no complications such as mucosal tearing and perforation were seen. The patient slept well on the day after treatment, and the blood gas was rechecked the next day: PH 7.431, PCO2 45.2 mmHg, PO2 58 mmHg, HCO3 30.0 mmol/L, BE 6mmol/L, SO2 90%. Prolonged conversation with others without episodes of coughing and wheezing. Physical examination: slightly enhanced tactile fibrillation bilaterally in the chest, clear sounds on percussion in both upper lungs, solid sounds in some parts of both lower lungs, and occasional croup on auscultation in both lungs. After 2 months of follow-up, the patient had no cough, wheezing and other respiratory symptoms, only slight acid reflux after dinner, no heartburn, regurgitation, etc. He took omeprazole occasionally and did not take other drugs, and could take care of himself and do daily chores.