Pearly papules on the penis can be treated without the use of medication. However, if there is localized infection, accompanied by pain, or accompanied by redness and swelling of the foreskin and glans, a small amount of erythromycin ointment can be used and applied externally 3 times/day, or a small amount of Bactrim ointment can be used and applied externally locally 3 times/day, and then discontinue the medication after the redness and swelling, and pain subside. If the pearly papules are scattered and have a psychological impact on the patient, laser cauterization or freezing may be considered for removal. After the removal of the external application of a small amount of moist scalding cream, 3 times / day, 5 consecutive days of external application, can also be circumcision, it can effectively reduce the incidence of pearly pimples, and after circumcision, some patients may have the possibility of self-healing. After surgery, you can use iodophor solution for local disinfection, you can also take cefixime capsule 1 capsule/times, 2 times/day, orally for a day to prevent infection treatment.