Vesicles on the mouth is generally caused by herpes simplex virus infection, this herpes is mainly manifested in the perioral cluster of cluster-like blisters, can gradually form ulcers, mostly self-healing, the course of the disease is generally in about a week, but easy to recurring episodes, the treatment can be externally coated with acyclovir ointment, oozing more can be used to rehabilitate the new solution of wet compresses. For patients with fever, fatigue, lymph node swelling and pain, oral antiviral drugs, such as acyclovir, vasiclovir, etc., perioral skin damage is more serious, or the infection symptoms are more serious patients, usually need to use antiviral drugs intravenously. Diet should be strengthened with nutrition, more vegetables and vitamin-rich fruits, more water and rest. For patients with recurrent episodes, medications to improve the body’s immunity should be given.