High erythrocytes in the urine routine can be seen in a variety of diseases, such as acute glomerulonephritis, chronic glomerulonephritis, IgA nephropathy, acute cystitis, as well as stones, tumors, or, less commonly, paroxysmal sleep hemoglobinuria. If it is caused by glomerulonephritis, urinary aberrant erythrocyte examination can be performed, and if the aberration rate is greater than 85%, glomerulonephritis is considered to be of glomerulonephritis origin, and renal preservation therapy is required. If it is caused by stones or tumors, the number of red blood cell aberrations is in the normal range, and it is necessary to actively treat the primary disease, such as lithotripsy or anti-tumor therapy. If it is caused by urinary tract infection, antibiotic treatment is needed. If it is paroxysmal sleep hemoglobinuria, it is necessary to further pass the acid hemolysis test, or direct or indirect anti-human globulin test and other tests to clarify the diagnosis. If necessary, consult the hematology department for regular anti-tumor treatment.