The protection period of BCG vaccine is generally 10 to 15 years, and the exact time should be judged according to the individual’s physical condition. Healthy newborns should be immunized with BCG vaccine 24 hours after birth, which is generally divided into two ways: intradermal injection and scratch. BCG vaccination can increase resistance and immunity to tuberculosis disease, and is currently an effective means of tuberculosis disease prevention. Resistance to TB bacteria increases with age, and usually adults do not need to be vaccinated. The protection period of BCG vaccine is not lifelong. After BCG vaccination, the duration of inoculated antibodies in the body will gradually diminish with the growth of time, and the speed of diminution varies from person to person. According to “Epidemiological Analysis of Tuberculosis among Students in Shuyang County, 2008-2017”, it is reported that the antibodies can generally decline to the standard of non-significance after 10 to 15 years. In most cases, babies can be vaccinated at the hospital of delivery after birth. If vaccination is not available, BCG vaccination should be given in a timely manner at a vaccine-accessible hospital or the CDC in order to minimize the risk of TB infection.