IgG is a large molecule protein, the increase of IgG in urine can be seen in physiological, but also can be seen in pathological, such as kidney disease. 1. Physiological: strenuous exercise, cold, fever, nervousness, sympathetic nervous excitement may lead to abnormalities in this index, at this time, pay attention to rest, avoid fatigue, regular review; upright proteinuria, lying down and resting can disappear on their own, mostly occurs in thin and tall body type of young people, for this kind of patients need to increase body weight, pay attention to the review. 2. Pathological: if the urinary macromolecular protein discharge increases, suggesting that the glomerular injury is more serious, the basement membrane permeability increases, so that the macromolecular IgG leakage, is the glomerular filtration membrane selection of permeability abnormalities of the important indicators. Increased IgG in urine can be seen in diseases with increased permeability of glomerular filtration membrane such as acute nephritis syndrome, acute progressive glomerulonephritis, nephrotic syndrome and so on. Elevated IgG in urine is recommended to consult with regular hospitals for standardized examination and treatment under the guidance of physicians.