Waking up early from 1 to 3 o’clock is a manifestation of insomnia, and the attribution of paeonia lactiflora and dihuangwan has a certain regulating effect on insomnia and early waking up caused by yin deficiency and blood deficiency, as well as liver and kidney deficiencies, and it is necessary to comply with the doctor’s instructions for the use of medication. Insomnia is a sleep disorder, mainly manifested as difficulty in falling asleep, or easy to wake up after falling asleep, early awakening, so 1 to 3 o’clock early waking up is also a manifestation of insomnia. The causes of insomnia in Chinese medicine may include deficiency of qi and blood, internal disturbance of fire-heat, yin deficiency and fire exuberance (deficiency of yin and essence in the body, resulting in hyperactive fire), and deficiency of heart and gallbladder qi. Gui Shao Di Huang Wan is composed of Angelica sinensis, Cornu Cervi Pantotrichum, Mudan Pi, White peony in wine, Radix Rehmanniae Praeparata, Poria, Chinese yam, Zedoaria. It has the effects of tonifying yin and blood, nourishing liver and kidney, and clearing deficiency heat. This product is used for dizziness, dry throat and tinnitus, soreness and pain in the waist and legs, afternoon hot flashes (a burst of heat) and heel pain caused by deficiency of liver and kidney and deficiency of yin and blood. Adverse reactions to this product are not clear, and it is contraindicated for those who are allergic to this product. Therefore, for insomnia caused by deficiency of yin and blood, or deficiency of liver and kidney, taking Qui Shao Di Huang Wan can help to regulate it, but it should be used under the guidance of doctor’s diagnosis.