Many people have the question that it is understandable to have pain after the appearance of shingles, but why do you still have pain after the herpes has healed? Why do you still have pain when there is no more skin problem? (See Figure 1 and Figure 2) Liu Botao, National Pain Clinic, China-Japan Friendship Hospital Watson and Loeser proposed in 2001 to define postherpetic neuralgia (PHN) as those with persistent pain for more than 1 month after clinical cure of acute herpes zoster. From the domestic and foreign pain medicine clinical point of view, postherpetic neuralgia is undoubtedly one of the intractable pain disorders plaguing the middle-aged and elderly population, and is recognized as a world-class painful disease. Postherpetic neuralgia is an intractable pain disorder that occurs 3 to 6 months after the herpes has subsided and lesions have formed, and its pathological changes are different from those of herpes zoster, which is an independent disease. The typical symptoms are: painful, untouchable skin at the site of the original herpes, even rubbing of clothes can cause burning pain or pins and needles, numbness or itching in the painful area, and persistent pain. It is often difficult to heal and causes great pain to the patient. Figure 1 This is a manifestation of acute herpes zoster. Figure 2 The area marked by the black and red lines is the area where postherpetic neuralgia occurs.