The fever-reducing medication of the buttocks plug is mainly incorporated through the anus to allow the drug to reach the rectum, through which the drug components are absorbed and thus act on the whole body. The main component associated with it remains the anti-inflammatory drug that is antipyretic and analgesic, and the main component can include acetaminophen, but also indomethacin. For children the main choice is acetaminophen suppositories, which can be compounded pediatric antipyretic suppositories, which contain other ingredients such as artificial oxymorphone in addition to the main component of acetaminophen. Adults can choose suppositories of indomethacin, which also acts in the rectum and then reaches the whole body. The advantage of rectal administration is that the first-pass metabolic effect of the liver can be avoided, allowing the drug to have a greater effect. In addition, when the patient vomits after taking the drug orally, or is simply unable to take the drug orally, rectal administration is an option in this case.