If cholangiocarcinoma metastasis occurs in intra-abdominal retroperitoneum and enlarged lymph nodes are seen in the abdominal cavity, it is usually necessary to do tumor and lymph node resection with radiotherapy, chemotherapy, or conservative treatment, and regular rechecking. If bile duct cancer metastasis occurs and there are swollen lymph nodes in intra-abdominal retroperitoneum, first of all, it should be identified whether it is caused by inflammation or not. Inflammatory enlargement can be improved by oral or intravenous injection of cephalosporins or other antibiotics, and then it can be continued to complete the standardized treatment course of antibiotics. For lymph node enlargement caused by tumor metastasis, surgery is usually needed to remove the tumor, metastatic foci and surrounding enlarged lymph nodes, and at the same time, combine with the pathological type of the tumor, staging, and physical status to make appropriate radiotherapy; if there is no indication for surgery, only radiotherapy or other conservative treatments can be carried out; pay attention to the regular review, monitor the changes of the condition, and adjust the treatment in a timely manner. If tumor metastasis and lymph node enlargement are found, it is suggested that patients should pay attention to rest, avoid exertion, have reasonable diet, keep optimism, face positively, and seek medical treatment to control the condition in time.