Case 1: Female, 46 years old, worker, unexplained weakness, anemia, hematocrit 8.5g, usually healthy, menopausal, eating well, sleeping well, no blood in stool. She had always thought it was a blood problem, but the hematology examination showed no abnormal findings except for anemia, and the gastroscopy showed no abnormal findings. Finally, we suggested her to have a fiberoptic colonoscopy, which revealed a mass in the ascending colon, and the surgery and pathology confirmed that it was colon cancer. Case 2, Zhu Jianwei, Department of Gastroenterology, Nantong University Hospital: Male, 48 years old, teacher, had left lumbar pain for more than a year without any other discomfort. He thought it was lumbar muscle strain and took some drugs to relieve muscle pain. Recently, the pain was more severe, so he came to the hospital for physical examination and had a CT examination, and found a mass in the descending colon. Surgery revealed that it was colon cancer, located in the posterior wall of the colon and invaded backward to involve the lumbar muscle. The discomfort in the lumbar region turned out to be caused by colon cancer invasion, and the lumbar symptoms were relieved after surgery. Case 3: Female, 53 years old, a teacher, had hidden pain in the right lower abdomen for many years and was diagnosed as chronic appendicitis, which improved with the application of anti-inflammatory drugs. Recently, the pain in the right lower abdomen increased and she came to the hospital for consultation, and the diagnosis of acute attack of appendicitis was proposed. During surgery, the appendix was found to be normal, and there was a tumor in the cecum with perforation formed backward. Since the cecum is an interperitoneal organ, the posterior perforation of the tumor is limited by the peritoneum, unlike the anterior wall perforation which can lead to diffuse peritonitis (widespread abdominal pain). It presents only as localized pain. These cases remind us (and also doctors) that chronic discomfort in the body should be taken seriously enough. Do not take it for granted that it is a benign problem and delay the condition. The incidence of tumors is increasing year by year, and the age of onset is getting younger and younger. Many chronic discomfort in the body is caused by benign diseases, but don’t forget the possibility of malignant tumors.