There is no fastest treatment for heat rash, but the condition can be relieved by cool and itch-relieving lotions or powders, hormones, and oral medications. 1. Cooling and anti-itching lotion or powder: heat rash patients can use topical prickly heat powder or peppermint glycerine lotion to improve the condition, while pustular prickly heat is recommended to use ichthyol glycerine lotion or Huanglian puffing powder, but the specific use of medication need to follow the doctor’s instructions. 2. Hormone: patients with red prickly heat, can be used locally glucocorticoid cream, such as tretinoin ointment, hydrocortisone ointment, etc., these drugs can reduce itching symptoms, and accelerate the inflammation subside. 3. Oral medicine: heat rash can be orally administered drugs such as antihistamines, antibiotics, etc., of which the former is suitable for patients with obvious itching, commonly used diclofenac tadalafil dry suspension. The latter is suitable for patients with serious pus rash infection, commonly used doxycycline, tetracycline and so on. When using the relevant drugs for heat rash treatment, you need to strictly follow the doctor’s instructions, do not use your own medicine, so as not to cause adverse consequences.