The price of biologics for ankylosing spondylitis ranges from hundreds to thousands of dollars because of the type of biologics used, dosage, course of treatment, and manufacturer. Currently, biologics for the treatment of ankylosing spondylitis include tumor necrosis factor inhibitors, mainly infliximab, etanercept, and adalimumab. The price fluctuates from hundreds to thousands of dollars depending on the type of drug, dosage, course of treatment, manufacturer, different hospitals, different cities, different health insurance policies, and the material and dosage of a single injection of biologics. Some of the drugs are now included in the medical insurance, and the cost of treatment is significantly lower than before. Biological agents play an important role in the treatment of ankylosing spondylitis, but there will be adverse reactions, common headache, chills, fever, upper respiratory tract infections, etc. Pregnant or breastfeeding women, acute infections, malignant tumors, patients with old tuberculosis or viral hepatitis is prohibited. Ankylosing spondylitis is a chronic disease, treatment is a long-term process, patients should be under the guidance of the doctor, scientific and correct use of biological agents.