HPV E6E7 refers to the human papillomavirus (HPV) genes E6 and E7, which have the potential to turn negative after infection, with an undetermined probability. Both are early transcribed genes, so they are commonly used to test for the presence and extent of HPV infection.HPV infection is usually a necessary but not sufficient condition for the development of cervical cancer, as only a small percentage of HPV-infected individuals will progress to cervical cancer. The use of antiretroviral therapy (ART) in HIV-infected patients may increase the rate of regression and decrease the rate of recurrence, and some infected patients may recover spontaneously, although the exact probability has not been clearly studied. If infected with HPV, further gynecologic cytology is recommended to determine the next step of treatment based on the cytology results. If intraepithelial neoplasia is present, the ideal management includes ideal excision or ablation therapy, topical medication after ablation therapy, initiation of ART, and clinical follow-up.