Cholangiographic opacities in patients with Dubin Johnson syndrome often refer to opacities with oral contrast, which are caused by gallbladder malabsorption due to defects in the gene for the multispecific organic anion transporter protein on capillary bile ducts. Dubin Johnson syndrome, also known as chronic idiopathic jaundice, is mostly hereditary, due to gene defects in the multi-specific organic anion transporter proteins on the capillary single ducts, with malabsorption of the gallbladder, serum bilirubin is often increased, and chronic or intermittent jaundice occurs, which can be deepened due to surgery, alcohol consumption, etc., and accompanied by pain in the hepatic area, hepatomegaly, and other symptoms. The oral contrast agent cannot be concentrated after entering the gallbladder, and the gallbladder is not visualized on cholangiography, but the excretion test can show a normal liver, bile ducts and gallbladder. Intravenous cholangiography can be used. The contrast agent used in the intravenous method does not need to be concentrated to visualize the gallbladder and is not affected by absorption factors in the gastrointestinal tract. It is recommended that all tests be performed under the supervision of a physician.