Prevention of monkeypox virus needs to do to control the source of infection, cut off the transmission channels, if necessary, can be vaccinated with smallpox vaccine prevention. 1. Control the source of infection. Monkeypox virus is resistant to dryness and low temperature, and can survive for months on soil, scabs and clothing. Monkeypox virus can also infect rodents such as tree squirrels, primates such as monkeys and orangutans, so these animals are important sources of infection. Humans can also continue to infect others after being infected, so the infected need to be isolated. 2. Cut off the transmission route. In endemic areas, it is important to avoid contact with wild animals and avoid being bitten or scratched. If you are scratched or bitten by a suspected animal in an endemic area, be sure to check whether the animal is at risk of infection and seek medical help as soon as possible. Monkeypox virus can also be transmitted through close human-to-human contact and droplet transmission, so be sure to take good personal protective measures and maintain a social distance in endemic areas. Wear masks and gloves when contacting patients, and avoid direct contact with objects contaminated by exudate from patients’ skin lesions. 3. Vaccination. Some countries have started to vaccinate against monkeypox, but there is no vaccine for monkeypox prevention in China. People with special travel needs in endemic areas can consult with local specialized agencies.