The cause of Crohn’s disease is still unclear, but it may be closely related to immune factors, infectious factors, and genetic factors. 1. Immune factors: local immune response can be induced by intestinal pathogens crossing the mucosal epithelial barrier and coming into direct contact with the relevant immune cells in the follicular fornix area, thus leading to the occurrence of Crohn’s disease. 2. Infectious factors: Mycobacterium avium subspecies paratuberculosis or measles virus inclusion bodies can be found in the tissues of patients with Crohn’s disease, suggesting that infection may have a role in the development of Crohn’s disease. 3. Genetic factors: there are obvious racial differences and family aggregation in the development of this disease, and the incidence rate varies in different races, while research has found that there are certain genetic defects in this disease, which suggests that there is a genetic predisposition to this disease. In addition, it is recommended that patients with Crohn’s disease go to the hospital in time to avoid delay.