EVB-positive diffuse large B-cell lymphoma can be treated by radiotherapy, stem cell transplantation and surgery. 1. Radiotherapy: EVB-positive diffuse large B-cell lymphoma can be treated by using chemical drugs such as vincristine sulfate and cyclophosphamide to inhibit tumor cell division. At the same time, the tumor cells can also be killed by radiation, so that the primary foci and metastatic foci of the tumor can be gradually reduced, and the chemotherapy or surgery can control the growth and recurrence of the tumor. 2. Stem cell transplantation: if the effect of radiotherapy and chemotherapy is not good and there is relapsed and refractory diffuse large B-cell lymphoma, it can be treated by stem cell transplantation, which can inject normal hematopoietic stem cells into the body, so as to make the hematopoietic function of patient’s body as well as the immune function return to normal. 3. Surgery: if the lymphoma is in special location, such as gastrointestinal lymphoma which may lead to perforation, bleeding and obstruction of digestive tract, the patient needs to be treated by surgery to remove the lymphoma in time in order to relieve the above symptoms. Patients with EVB-positive diffuse large B-cell lymphoma should go to the hospital and choose the appropriate treatment under the guidance of the hospital for treatment.