Semen routine leukocytes + is mainly due to genitourinary infections, which may be caused by seminal vesiculitis, prostatitis, orchitis and other causes. 1. Seminal vesiculitis: mainly due to inflammation caused by Klebsiella aerogenes, Aspergillus and other pathogenic bacteria infection. Due to the stimulation of inflammation and the fact that the seminal vesicles are the main storage location for semen, the body’s immune response can order the white blood cells to kill the foreign pathogenic bacteria, which can lead to the phenomenon of semen routine leukocytes +. 2. Prostatitis: the pathogenesis and pathology of prostatitis are not yet very clear, and may be related to pathogenic bacterial pathogen infection. When collecting semen, there may also be the presence of prostate fluid. When there is inflammation, thus the phenomenon of semen routine leukocytes + can appear. 3. Orchitis: is an inflammatory disease of the testes caused by bacterial or viral infection. Testicles have the role of sperm production, when testicular inflammation, can also appear semen routine leukocytes + phenomenon. It is recommended that patients with semen routine leukocytes + go to the hospital in time and follow the doctor’s instructions for treatment to avoid delaying the condition.